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On initial observation, the principle behind the theory of cysteine deficiency being a cause of low glutathione appears reasonably sound, but it is not that simple
Nevertheless, metformin remains the typical first-line choice because of its well-established safety profile, efficacy, low cost, and wide accessibility (Wexler 2021b)
Before committing to combination therapy, it is worth stepping back and asking a blunt question: does adding phentermine to tirzepatide actually provide enough additional benefit to justify the added risk, monitoring burden, and cost
It'd be more accurate to say there's overlap, but it's also like, you want to get the most robust from all of them, right
2 for the metabolic pathways affected by CYP450)
