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These amphipathic molecules are made from cholesterol and are synthesized and conjugated in the liver
The population primarily had obesity (Class 1 [BMI 30-35]: 30.9%, Class 2 [BMI 35-40]: 26.2%, and Class 3 [BMI 40+]: 31.5%) compared to overweight (BMI 27-30: 11.3%)
Miguens-Gomez 2021): A fast, neural-based release within 10-15 minutes of eating A slower, nutrient-based release ~60 minutes after eating, especially when nutrients reach the lower GI tract, Eating too quickly may short-circuit the gut-brain connection
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