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The answer lies in how NAD must be administered

Enhances free radical scavenging* Provides the three precursors needed to form glutathione within the body: N-acetyl-L-cysteine (NAC), glutamic acid and glycine* How It Works / Key Ingredients Glutathione, or y-glutamyl-cysteinylglycine (GSH), is the primary intracellular antioxidant involved in preventing lipid and protein oxidation

Additionally, ROS can promote the recruitment and activation of immunosuppressive cells, such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), which further inhibit the anti-tumor immune response and facilitate tumor progression [123]

PMID 14672298