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The number of clusters (k=5) was chosen objectively by maximizing a combined score of: Silhouette coefficient on a discovery split: measures how well-separated the clusters are internally Adjusted Rand Index (ARI) on a held-out validation split: measures whether an independent reclustering of new data produces the same structure This two-stage validation approach guards against over-fitting the cluster count to a single sample

Rankings reflect community discussion patterns among Reddit users, which are not representative of all GLP-1 users

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AST, 97.9 19.5) (Ahmad et al., 2016)

Extensive clinical experience has been reported using these medications in a wide spectrum of patients with T2DM and concomitant cardiovascular disease, chronic kidney disease, or obesity, among others