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Animal studies showed no evidence of impaired fertility or fetal harm, however at 600 mg/kg daily there was a statistically insignificant increase in post implantation losses

24: 177682 Apfel SC, Kessler JA, Adornato BT, et al., for NGF Study Group

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The mean differences between the treatment and placebo groups were approximately 12 centimeters across the two trials. The trials also reported: Mean trunk-fat reductions of approximately 0.81.0 kilograms Mean lean-body-mass increases of approximately 1.21.3 kilograms Little overall change in total body weight These results suggest that tesamorelin can alter the distribution of fat and lean tissue without functioning as a conventional weight-loss agent