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The Importance of FIH Trials in Clinical Development First-in-Human trials provide the first opportunity to translate preclinical evidence into early clinical knowledge

Dyspnea, tachyarrhythmias Increased blood pressure, widened pulse pressure Aortic systolic murmur Congestive heart failure Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body

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3.2 Abnormal cardiac energy metabolism In the state of diabetes, the hearts metabolic processes experience substantial alterations because of a changed metabolic environment marked by hyperglycemia, hyperlipidemia, and insulin resistance (51)