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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)
In clinical use, significant side effects are uncommon, and the vast majority of patients tolerate the therapy without problems
Exposure to light, heat, and air can degrade the solution, reducing its effectiveness
physician reassesses at follow-up Administration Oral capsules
However, in human systems the outcome of boosting NAD+ is complex and likely involves numerous pathways, from enhanced activity of sirtuins (implicated in longevity and metabolic control) to improved DNA damage repair, all of which are areas of ongoing investigation
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