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S.ZhuL.JiangG.et al
With one amino acid substitution, MT-1 maintains strong binding to MC1R, which makes it especially valuable in pigmentation-centered research models
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Furthermore, it provides a critical appraisal of recent human observational data, distinguishing metabolic benefits from intrinsic disease-modifying effects, and outlines the practical clinical friction points and prospective trials necessary to validate these pathways in future treatment paradigms
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