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A Novo Nordisk spokesperson pointed out that NAION is not listed on approved labels as an adverse drug reaction for the marketed formulations of semaglutide. They also noted limitations in the Mass Eye and Ear study, such as its small and non-randomized sample group

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(2) Ipratropium acts as a competitive antagonist at muscarinic receptors in bronchial smooth muscle, inhibiting acetylcholine binding and blocking parasympathetic-mediated bronchoconstriction