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Adults receiving multiple daily injections and those using an insulin pump or automated insulin delivery system had similar reductions in BMI and HbA1c with both semaglutide and tirzepatide, though there were trends showing greater decreases for insulin pump users

However, recent studies and reports have linked Ozempic and other GLP-1 medications to serious gastrointestinal side effects like gastroparesis, intestinal blockages, and ileus

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In men, declining testosterone after 50 contributes to both muscle loss and increased visceral fat accumulation