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Most surgeons will not even try to operate on these as surgery doesnt help and meniscectomy can make the knee worse
Each freeze-thaw cycle creates ice crystals that can physically disrupt peptide structure, and the process concentrates the peptide at the boundary between frozen and unfrozen regions, potentially causing aggregation
Janas KM, Cvikrov M, Paagiewicz A, Szafranska K, Posmyk MM (2002) Constitutive elevated accumulation of phenylpropanoids in soybean roots at low temperature
