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Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field
IF also promotes the production of short-chain fatty acids (SCFAs), including butyrate, which serves as a primary energy source for colonocytes and exerts potent anti-inflammatory effects throughout the gastrointestinal tract and beyond [81]
Known causes include: Around one-third of people with diabetes (Type 1 or Type 2) develop gastroparesis
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