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In summary, the reported inactive GLP-1R crystal structure reveals a unique closed conformation of the ECD, and a deeper understanding of the conformational dynamics of GLP-1R was elaborated by EM and MD simulations
doi:10.1111/jnc.12469
These treatment conditions were chosen to mimic excess heme from chronic hemolysis and systemic hypoxic conditions that occur in SCD patients 1,2,11
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