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Mitochondrial dysfunction and cellular senescence, rather than telomere shortening, are demonstrated to be associated with neurodegenerative diseases (PD, PDD, and Lewy body dementia (LBD)) using blood and prefrontal cortex brain tissues from two different cohorts, suggesting that mitochondrial dysfunction in the blood may serve as a valuable early marker for PD risk [88]

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Acetyl-L-carnitine influences the fluidity of brain microsomes and of liposomes made of rat brain microsomal lipid extracts Neurochem Res 1992