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The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock

Activated microglia release reactive oxygen and nitrogen species, pro-inflammatory cytokines, and other neurotoxic mediators that exacerbate oxidative stress and mitochondrial damage

doi: 10.1002/fsn3.2298 94

More severe conditions may require multiple injections or other treatments in addition to cortisone

The brain then sends messages to organs important in glucose regulation, notably the beta cells in the pancreas, where secretion of insulin is increased, and the liver, to inhibit output of glucose into the bloodstream (Waise et al., 2018