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Instead of following the standard titration schedule, where you increase your dose every four weeks until you hit the high maintenance level, microdosers stay at the lowest effective dose for months, or even take less than the starting dose

Side effects and how to manage them KLOW is generally well-tolerated, but side effects can occur, particularly during the introduction phase or after dose increases

They highlighted that, fortunately, the absolute increase in risk is quite low given that NAION occurs quite infrequently in the general population

However, the company denies that this delayed gastric emptying causes gastroparesis

The SURMOUNT-1 trial [1] showed 22.5% weight [1] loss at 72 weeks with retatrutide 12mg, establishing its potency compared to single-receptor agonists