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In addition, gene therapy based on transfection of mtDNA-complexed TFAM or recombinant TFAM to PD cybrid cells shows potential to restore mitochondrial bioenergetics of severely impaired nigral neurons, as TFAM is important for mtDNA maintenance (Keeney et al., 2009
doi:10.1016/j.ctim.2019.102201
However, most of the studies are done on animal models
The study noted strongly stimulated dermal keratinocyte proliferation, indicating active tissue regeneration rather than merely surface effects
Liu S, Liu F, Jia H, Yan Y, Wang H, Guo X
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