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GLP-1RA Therapy as a Chronic Flux Perturbation System-Level Energy Flux Reorganization Under Weight Loss Therapy Most weight-loss interventionsincluding exercise [49], calorie restriction [50], cold exposure [51], and selected antidiabetic agents [10, 52]ultimately increase reliance on FAO, which supplies acetyl-CoA to sustain tricarboxylic acid (TCA) cycle activity and electron transport chain (ETC)coupled adenosine triphosphate (ATP) production
Consistent with our results, GLP-1 analogue could also reduce the phosphorylation of both Smad2/3 in Ang II-induced cardiac fibrosis, enhance bone morphogenetic proteins (BMP) signaling [37] which in turn inhibited TGF-/Smad2/3 signaling, and decreased the phosphorylation of ERK1/2 in vascular smooth muscle cells [38, 39]
Statements Author contributions ST: Methodology, Conceptualization, Supervision, Investigation, Writing original draft, Software, Resources
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