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GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)are widely prescribed in the UK for type 2 diabetes and weight management
In vitro and in vivo studies have shown that orforglipron, as a non-peptide agonist, has a different signalling profile compared to classical GLP-1 peptide analogues - including different activity towards -arrestin
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Multiple electronic databases were systematically searched, including PubMed/MEDLINE, Embase, Cochrane Library, and Google Scholar, covering publications from January 2020 to April 2025
Therapeutic Potential of Semaglutide, a Newer GLP-1 Receptor Agonist, in Abating Obesity, Non-Alcoholic Steatohepatitis and Neurodegenerative diseases: A Narrative Review
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