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This is characterized by the accumulation of low-density lipoprotein within the artery walls, leading to the formation of atheroma and distinct plaques consisting of proliferative fibrous tissue and calcifications (109, 110)
reported that unexplained liver injury in PCOS patients and animal models was accompanied by increased Fe deposition and downregulation of hepcidin and GPX4 expression in the liver, indicating the importance of iron metabolism in this type of unexplained liver injury (165)
In the landmark LEADER trial , liraglutide was shown to reduce the risk of major cardiovascular events including heart attack, stroke, and cardiovascular death in people with type 2 diabetes at high cardiovascular risk
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