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If you are curious about the differences between semaglutide and tirzepatide in clinical terms, the receptor difference is the starting point for that entire conversation
Injectable GHK-Cu was in Category 2 the more restrictive category for substances with "significant safety concerns." Its removal from Category 2 is the more positive development, as it signals the FDA no longer considers injectable GHK-Cu to carry the safety risk level that warranted Category 2 placement
Until it does, the evidence-based position is to not use Dihexa
This is supported by observations that blood homocysteine decreases in individuals undergoing male to female transition, and vice versa in those undergoing female to male transition (22)
The effect on truly "stubborn" subcutaneous fat (which is resistant due to higher alpha-2 adrenergic receptor density) is unclear
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