Both Hesperetin- and Naringenin-treated mice exhibited significantly improved impaired glucose tolerance and insulin sensitivity, as evidenced by lower blood glucose before and during OGTT (Figure 7D) and a greater glucose-lowering response to exogenous insulin in ITT (Figure 7E)
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The good news is these side effects tend to decrease and go away within the first two months

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These include: Nausea (often most pronounced during dose escalation) Vomiting and diarrhoea Constipation Abdominal discomfort and bloating Reduced appetite (therapeutic effect but may be excessive) These symptoms typically diminish over 48 weeks as tolerance develops