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Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr
Phase 3 trials are the large-scale, randomised controlled studies required to establish efficacy and safety across diverse patient populations before a regulatory submission can be made
Unlike synthetic Wnt agonists, which can create unwanted off-target stimulation, the tripeptide appears to nudge Wnt signaling within a biological operating range
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