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Imrie, C

Confirm identity is supported by LC-MS or mass spectrometry

The American Diabetes Association (ADA) guidelines recognize GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who require additional glucose-lowering therapy beyond metformin, particularly those with established cardiovascular disease or chronic kidney disease, with preference given to agents with proven cardiovascular benefit

Exenatide treatment and co-infusion of d3-leucine 5 h after starting continuous infusion of lipid/carbohydrate formula in healthy fasted humans via nasoduodenal tube 2 h after starting a pancreatic clamp does not significantly affect plasma TG, FFA, or TRL-TG compared to placebo (Xiao et al., 2012)