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Semaglutide carries an FDA boxed warning for thyroid C-cell tumors seen in rodent studies, and it is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or MEN 2
Decisions are shaped by a combination of medical, practical, and individual factors, rather than a single criterion
This comparison breaks down what each does, how they differ, and why their combination (CagriSema) may represent the next leap in obesity pharmacotherapy
Some people report feeling more anxious around eating, trapped in cycles of all-or-nothing thinking, or pressured to keep chasing thinness (Meule and Kbler, 2024)
Meet our doctors Last reviewed: 02 Jun 2026 Sources Saxenda 6 mg/mL solution for injection in pre-filled pen, EMC [accessed 26 January 2026] Wegovy 1 mg, FlexTouch solution for injection in pre-filled pen, EMC [accessed 26 January 2026] Accessing Wegovy for weight loss: Everything you need to know, Gov
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