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Research suggests that oral melatonin, at doses of 25 mg taken at night, can significantly reduce the Melasma Area Severity Index (MASI) score

Aids in cortisol regulation and utilization of B vitamins. Adaptogenic herbs and mushrooms Herbs such as KSM-66 Ashwagandha Extract, Rhodiola rosea, Siberian ginseng, American ginseng, and Schisandra along with the mushroom cordyceps, belong to a category of medicinal plants known as adaptogens

FIGURE 3 Clinical studies have reported controversial results despite the support from preclinical studies (Table 2)

The short answer is: When your healthcare provider recommends it

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