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Post-hoc HPLC analysis of retained samples confirmed greater than 70% degradation

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These peptide hormones mediate their biological actions through five different but closely related G-protein coupled melanocortin receptors (MC1-R to MC5-R) that are distributed in many tissues and involved in the regulation of important physiological functions including skin pigmentation, steroidogenesis, energy homeostasis, sexual function, and exocrine secretion (Yang, 2011)