retatrutide mechanism of action triple agonist glp-1 gip glucagon A review an investigational drug retatrutide, a novel agent for the treatment of obesity | European Journal of Clinical Pharmacology Retatrutide vs Tirzepatide (2026): Differences

The SURMOUNT-1 trial on tirzepatide pushed that even further, up to 22.5 percent in some participants

The GIP component enhances fat tissue function and further supports appetite control

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