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In mouse experiments, Klevay and Viestenz (116) observed that copper-deficient rats exhibited a range of electrocardiographic abnormalities, including ST-segment depression spanning one-third to one-half of the RR interval, bundle-branch block with R-wave heights and widths three times the normal values, Q-waves, and second- and third-degree heart block

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Presence of B12-blocking drugs or hormones

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It is yet unclear how ferroptosis and other cell death mechanisms interact, and research is needed to understand their cross-regulatory networks utilizing genetic engineering models like GPX4/ACSL4 double knockout systems