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Although routine B12 supplementation in patients on metformin therapy is not the standard of care (279), it is reasonable to monitor vitamin B12 levels in patients on metformin, particularly for individuals on long-term metformin (102
Vitamin B6, Mayo Clinic
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Changes related to fat metabolism or body composition typically take longer and are usually noticed after 34 weeks of consistent use, especially when combined with a healthy diet and activity plan
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