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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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Low dose naltrexone (again-alone!) resulted in significant clinical improvement in 75% of these patients, with complete remission noted in 25%

Neurotherapeutics 18(2):949961 Vellimana AK, Diwan D, Clarke J, Gidday JM, Zipfel GJ (2018) SIRT1 activation: a potential strategy for harnessing endogenous protection against delayed cerebral ischemia after subarachnoid hemorrhage