glutathione s transferase mu antibody s-transferase 1 Human S‑Transferase 1/GSTM1 MAB6894: R&D Systems View Rabbit Polyclonal anti Glutathione S-transferases in kidney and – Anti-Glutathione S Transferase mu antibody

D.LiuY.SellkeF

Sui et al., 2013)

Key principles of conjugation: All six pathways require specific cofactors (nutrient deficiencies directly impair detoxification) Competition exists between pathways when a single substrate can be conjugated by more than one enzyme Conjugation does not always produce a less toxic product (some sulfation and acetylation reactions generate reactive metabolites) Conjugated products must still be transported out of the cell via Phase III transporters (MRP, P-gp, BCRP) for excretion R Bile is the primary excretion route for large, glucuronidated, and glutathione-conjugated metabolites Urine handles smaller, sulfated and acetylated conjugates The balance between Phase I activation and Phase II conjugation is critical

STORAGE: Store at a temperature below 30C in dry place

Targeting HER2 (ERBB2) amplification identified by next-generation sequencing (NGS) in patients with advanced or metastatic solid tumors 17(1S), 2017