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Commonly used markers such as p16^INK4a, SA--galactosidase, and SASP cytokines (eg, IL-6, IL-8) show promise in experimental models but have variable sensitivity and specificity across tissues and disease contexts

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Depletion Over Time: The body uses Vitamin B12 continuously for vital functions, and its levels can deplete over time

These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

Additionally, some medications can affect glutathione levels