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The compound did not affect fasting glucose, insulin, HbA1c, IGF-1, cortisol, thyroid hormones, or liver enzymes (Thompson et al., 2004)
By inhibiting NNMT, 5-Amino-1MQ appears to improve how the body handles glucose
When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
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