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Jan 28 2021;125(2):121-128
Methionine supplementation at very high doses may increase homocysteine levels if B12 and folate are insufficient
The brain is the only part of the body that has depends entirely on B12 to detoxify
The C-terminal amidation is critical for full biological activity, as the free-acid form shows significantly reduced receptor binding
They have to be converted to the active form and are less potent than the pure, active ingredient. The difference between pure vitamin C and vitamin-C derivatives is similar to retinols and retinoids: Both work, but one is more concentrated and thus more effective
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