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People were able to maintain approximately 10% WL over a 4-year period, and the proportion of participants experiencing SAE during the trial was lower in those assigned to semaglutide 2.4 mg compared to placebo (33.4% vs
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At the same time, the pleiotropic, neurotrophic and neuroprotective properties of GLP-1RAs are also obvious and, taking into account the ability to enhance the energy metabolism of neurons and optimize synaptic plasticity these beneficial effects position GLP-1RAs as potential agents modifying brain diseases [109, 110]
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