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Therefore, when selecting the route of administration for semaglutide, clinicians should consider the risk of adverse events and weigh them against the clinical benefits
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However, because of the gradual dose escalation, the full effects on blood sugar and weight typically become apparent over 3-6 months as you reach the maintenance dose
Despite a large body of scientific research, GLP-1RA demonstrated a positive effect with a 14% reduction in major cardiovascular events (MACE) [HR=0.86, 95%CI(0.79-0.94), p =0.006] and no significant heterogeneity was observed between subgroups of individuals with or without cardiovascular disease ( p =0.127)
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