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Upon entering biological fluids (e.g., blood, cerebrospinal fluid), MPs/NPs rapidly adsorb biomolecules including proteins and lipids, forming a distinctive biomolecular corona. This corona enables MPs/NPs to traverse cellular membranes through passive diffusion, mediated by specific binding interactions between the adsorbed biomolecular corona and membrane components (Shannahan, 2017)
In wild-type mice, Cx32 abundance in hepatocytes decreased substantially as early as 1-h post-APAP treatment, reaching a 20% reduction compared to the steady-state or control group
May 2012;42(5):1529-39
It binds copper ions, helping activate enzymes that build collagen and elastin fibers
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