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Why Half-Life Matters for Dosing The half-life of Retatrutide is central to how it is administered and tolerated
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The SURMOUNT-1 trial demonstrated up to 22.5% body weight reduction with tirzepatide at the highest dose (15mg weekly), compared to semaglutide's 14.9% in STEP 1
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Alternating between semaglutide and tirzepatide on a weekly or monthly basis may prevent the receptor desensitization that contributes to stalls on either medication alone
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