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Retatrutide is a once-weekly subcutaneous peptide that simultaneously activates GIP, GLP-1, and glucagon receptors
A promising path is the strategic repurposing of compounds with proven safety profiles
Those with untreated or poorly controlled thyroid disease need endocrinology evaluation before starting, since semaglutide's effects on metabolism interact with thyroid function
Patients with rheumatoid arthritis considering or currently using GLP-1 medications should engage in comprehensive discussions with their rheumatology team to ensure coordinated, evidence-based care
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