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1,2 For the co-primary endpoints, retatrutide lowered weight by up to an average of 28.7% (71.2 lbs) and reduced pain by up to an average of 4.5 points (75.8%) using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score

PMID: 35471719 Mol Metab Vagal control of the brain-esophagus axis ameliorates stress-induced esophageal motility dysfunction in male mice

This is not simply a recommendation but a critical requirement for the medication to work as intended

Phase 2 trials testing higher doses suggest Mazdutides ceiling may extend considerably beyond the currently approved 6 mg