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Based on these studies and the functional form of native GLP-1 (736), chimeric proteins as potent GLP-1 agonists with an extended plasma half-life were engineered using a native or two modified human GLP-1 (mGLP-1) that were resistant to DPP-IV or both DPP-IV and trypsin cleavage and fused to a DARPin with high affinity and specificity for HSA
In rare cases, more serious risks can occur, such as pancreatitis, acute kidney injury, gallbladder issues
A: GLP-1 agonist therapy is suitable for individuals struggling with obesity or those who have not achieved significant weight loss through diet and exercise alone
Eating for pleasure or just wanting to eat
