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Early Phase 2 data published in the New England Journal of Medicine in 2023 showed considerable promise, but retatrutide has not yet received approval from the MHRA or EMA
VN: Supervision, Writing review and editing, Validation
Additionally, endothelial dysfunction may also lead to vascular-ventricular uncoupling and afterload mismatch, collectively implying a causal role of aging in HFpEF pathogenesis
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