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The prediction subsequently validated by further study: 1-MT exerted multiple beneficial effects in TLE, including correcting the overactivation of BDNF/TrkB, reducing oxidative stress, restoring the activity of mitochondrial complex I/IV and reducing neuronal death, ultimately lowering the frequency and duration of epileptic seizures [19]

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Fatty tissue can only accommodate a limited volume before the depot pressure forces solution back through the needle tract or causes painful tissue distension

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