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Description

The primary endpoint of the study is the time to the first occurrence of cardiovascular death, non fatal myocardial infarction (MI), non fatal stroke, or heart failure (HF) within 5 years of treatment

Mechanism of Action CJC-1295 : Acts as a GHRH analog , stimulating the initiation of GH pulses from the hypothalamus and pituitary

P.ChalfunL.et al

Valle A, Guillevin R, Valle JN

Researchers started 1,613 adults in the trial on 1 mg of orforglipron and increased the dose every four weeks until patients received 6 mg, 12 mg, and 36 mg, while other patients received a placebo