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When taken orally, semaglutide works by several complementary mechanisms: Enhances insulin release only when blood glucose is elevated Suppresses the release of glucagon, a hormone that raises blood sugar Slows stomach emptying, helping you feel fuller for longer May reduce appetite and caloric intake, underpinning its weight loss benefit This targeted approach helps reduce HbA1c and fasting plasma glucose, while also supporting significant, sustained weight loss in eligible patients