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Current evidence suggests the changes are more likely due to rapid weight loss, hormonal shifts, microbiome disruption, and dehydration rather than a direct drug effect
Applying a cold compress to the injection site for 10 seconds immediately before the injection can numb the area through localized vasoconstriction, though this is optional
Epilepsy : Metoclopramide can lower the seizure threshold, which increases the likelihood of experiencing seizures
Given retatrutide's superior Phase 2 weight loss data (24.2% vs 15-17% for semaglutide), priority review is possible
Suchankova, P., et al
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