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Consider staying at 7.5 mg if: You are losing 1 to 2 pounds per week consistently Appetite suppression is adequate to maintain a caloric deficit Side effects are minimal and manageable You are comfortable with the cost at this dose level Consider continuing to 10 mg if: Weight loss has plateaued for more than 3 weeks at 7.5 mg Appetite suppression has diminished significantly Your target weight is still far from current weight Side effects at 7.5 mg are mild and tolerable Many researchers use the troubleshooting guide to determine whether a dose increase is the right move or whether other factors like dietary compliance or sleep quality are affecting results

Dave KM, Pinky PP, D SM (2025) Molecular engineering of extracellular vesicles for drug delivery: strategies, challenges, and perspectives

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Newer options like retatrutide add a third receptor (glucagon) to the mix, which may further affect dietary needs and tolerances

The broader point the article makes, that weight indications trailed diabetes by a long way, still stands