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Spermidine has been shown to induce meningococcal capsule upregulation, increase meningococcal invasion by 5-fold, and enhance survival within macrophages (Kanojiya et al., 2022a)
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95% CI 0.67 0.95) in the confirmatory secondary outcomes, in addition to the reduced risk of the primary outcome events (HR 0.76
7 , e243604 (2024)
Cell death is a consequence of the decrease in ATP production which rapidly compromises ion (mainly due to halting Na + -K + pump) and acid-base homoeostasis
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