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Evidence-based : Ensuring clinicians understand the difference between serum B12 levels and clinically active B12 stores, and other suitable tests to determine deficiency as well as symptom resolution with sufficiently frequent treatment
When stored correctly and handled aseptically, bacteriostatic water is generally viable for up to 28 days following the first vial puncture
55 GalluzziL.Bravo-San PedroJ
The primary concern with hepatic impairment is a potential change in exposure to a drug that is extensively cleared by hepatic metabolism or biliary excretion via the liver, that could impact on the pharmacodynamic action or lead to adverse effects [19]
Injections are usually started monthly for 3 months and then will need to be continued every three months for life
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